Award details

The pre-B cell receptor, an essential check point during B cell development

Reference	BBS/E/B/00001150
Principal Investigator / Supervisor	Dr Inga-Lill Martensson-Bopp
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	1,429,559
Status	Completed
Type	Institute Project
Start date	01/01/1999
End date	31/12/2005
Duration	84 months

Abstract

B lymphocytes synthesise antibodies which make up our humoral immune response. Antibodies bind specifically to foreign antigens found on bacteria and viruses, which can then be disposed of by different routes. Individuals that lack antibodies are severely immuno-deficient and cannot clear the body of any infection that needs the assistance of antibodies. Antibodies can also be pathogenic, which is often the case when an antibody recognises auto (self) antigen; if severe this can lead to destruction of a particular tissue (autoimmunity). B lymphocytes can also become tumorigenic and a large proportion of adult lymphoid malignancies are of B lymphocyte origin. It follows that a greater understanding of the biological systems and processes that lead to proper development of B lymphocytes is of utmost importance. This increased understanding will provide insights that are relevant to, and can be exploited by, biomedicine.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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