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Gene targeting of putative imprinting control regions in Igf2

Reference	BBS/E/B/00001149
Principal Investigator / Supervisor	Professor Wolf Reik
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	1,019,640
Status	Completed
Type	Institute Project
Start date	01/01/1999
End date	31/03/2004
Duration	63 months

Abstract

Imprinted genes are those genes that are only active when they come from either the father or the mother. The mechanism of imprinting involves attachment of chemical groups (methyl groups) to the DNA to indicate whether the DNA comes from mother or father originally. The regions in which imprinted genes are differentially methylated may indicate important control regions for gene activity. We are eliminating these regions by deletion from the chromosomes in the mouse. This will enable us to determine their function in regulating imprinted gene expression. The identification of silencers, boundary elements and antisense transcripts is of particular relevance.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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