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Identification of imprinted gene clusters on mouse chromosome 7/human chromosome 11p15: their role in development and fetal growth
Reference
BBS/E/B/00001144
Principal Investigator / Supervisor
Professor Wolf Reik
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
1,143,058
Status
Completed
Type
Institute Project
Start date
01/04/1998
End date
31/03/2004
Duration
72 months
Abstract
A number of genes which are important for growth of babies in the womb are imprinted, that is only the paternal or the maternal gene is effective. We are studying a particular collection of these genes, which are located in the same chromosomal place. We are studying the effects of these genes on increasing or decreasing the size of the fetus in the mouse. In humans, mutations or other defects in these genes are linked to fetal overgrowth and cancers. Imprinted genes have key roles in mammalian development and they represent important risk factors in a number of genetic diseases and cancers. An interesting recent observation is that imprinted genes are apparently clustered, with genes in a cluster being functionally and mechanistically related.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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