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Accessory protein regulation of Inositol 1,4,5-trisphosphate receptor signalling and its downstream consequences

Reference	BBS/E/B/00001116
Principal Investigator / Supervisor	Prof. Llewelyn Roderick
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	1,158,589
Status	Completed
Type	Institute Project
Start date	01/01/2005
End date	30/09/2009
Duration	57 months

Abstract

Changes in intracellular Ca2+ levels regulate diverse cellular processes, including fertilisation, gene transcription, muscle contraction, and cell death. Increases in intracellular Ca2+ arise either as a result of its release from stores within the cell (the ER or SR) or by influx across the membrane that surrounds the cell. Both chemical and electrical signals can trigger these increases in intracellular Ca2+ concentration. The importance of carefully regulating Ca2+ is underlined by the consequences of its mis-regulation: stroke, irregular heart beats and heart failure, high blood pressure, some neurodegenerative diseases and cancer are all associated with aberrant Ca2+ signalling. My aim is to identify novel modes of regulation of intracellular calcium levels. This will subsequently provide insight into the interplay between intracellular signalling pathways and will establish novel links between the calcium signalling pathway and other intracellular pathways.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	Neuroscience and Behaviour
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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