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Award details
The cloning and expression of Drosophila G-protein coupled receptors activated by octopamine or neuropeptides related to neuropeptide Y
Reference
BBS/E/B/00001072
Principal Investigator / Supervisor
Dr Peter Evans
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
921,831
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/03/2004
Duration
84 months
Abstract
The project aims to clone two specific groups of G-protein coupled receptors from the genome of Drosophila. The receptors will be expressed in appropriate cell lines or Xenopus oocytes and their pharmacological and coupling to second messengers examined. The results of this project will help in the development of insect control agents with fewer side effects on man and non-insect wildlife. It will also increase our basic knowledge of how cells in nervous systems talk to each other. Octopamine and various neuropeptides function as neurotransmitters/neuromodulators in the insect nervous system. This project aims to use polymerase chain reaction (PCR) based approaches to exploit information contained in the recently completed Drosophila Genome Project to identify and clone seven transmembrane spanning putative G-protein coupled receptors activated by octopamine and various neuropeptides related to Neuropeptide Y. The clones for these receptors will be expressed either in Xenopus oocytes or in appropriate transfected insect or mammalian cell lines to define the pharmacological profiles of the receptors.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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