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Genetic control of T lymphocyte populations and markers

Reference	BBS/E/B/00001042
Principal Investigator / Supervisor	Dr Geoff Butcher
Co-Investigators / Co-Supervisors
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	856,316
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/08/2007
Duration	125 months

Abstract

Lymphocytes are the key players in the immune response. Individual variations in the ability to make particular immune responses, or in their quality, are often due to lymphocytes and their products. Similarly, lymphocytes are often the culprits in autoimmune disease, where they make inappropriate, damaging responses. This project aims to gain knowledge of the genetic factors underlying variations and malfunctions in immune responses, and of the impact of these factors on lymphocyte behaviour. As part of this project we focussed on the lymphopenia (lyp) mutation, which is a strong determinant of autoimmune diabetes in the BB rat. We have recently shown that the lyp gene is also predisposing for an inflammatory eosinophilic bowel disease of rats and are pursuing the basis of this syndrome in collaboration with colleagues in Oxford.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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