Award details

TSE agents in diverse environments: their biochemical and biophysical characteristics, detection and survival

Reference	BBS/E/A/00001657
Principal Investigator / Supervisor	Dr Robert Somerville
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	38,564
Status	Completed
Type	Institute Project
Start date	01/04/2007
End date	31/03/2010
Duration	36 months

Abstract

Detection and measurement of TSE agents depends on infectivity assays in animals, although in some cases measurement of PrPSc can be used as a surrogate. Exposure to harsh environments may alter the biochemical properties of TSE agents and their relationship to PrPSc. The overall aim of this project is to further characterise biochemical properties of TSE agents and PrPSc which may affect their recovery and assay. Sedimentable particles produced after a novel solubilisation treatment of PrPSc will be characterised biochemically and testing their association with TSE infectivity tested. The effect of physicochemical treatments which may alter the biochemical properties of TSE agents will be investigated. Binding to surfaces will be explored.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	Animal Health, TSEs (transmissible spongiform encephalopathies)
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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