Award details

Control of TSE incubation time by Polymorphism in PrP

Reference	BBS/E/A/00001650
Principal Investigator / Supervisor	Dr Rona Barron
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	108,269
Status	Completed
Type	Institute Project
Start date	01/04/2007
End date	31/03/2010
Duration	36 months

Abstract

Polymorphisms in PrP are thought to control TSE incubation time and susceptibility to disease, and several PrP mutations have been linked with the development of familial human TSE disease. However, the mechanisms by which alterations in PrP sequence affect disease transmission, or cause disease to occur spontaneously are unknown. This programme of work, using unique lines of gene targeted transgenic mice, is designed to study the effect of individual alterations in PrP on an identical genetic background, and determine the role of such polymorphisms/mutations in the disease process. We also aim to determine the role of PrP amyloid in TSE disease and whether it forms part of the TSE infectious agent or is instead formed as part of a protective mechanism against the spread of disease.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Animal Health, Neuroscience and Behaviour, TSEs (transmissible spongiform encephalopathies)
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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