Award details

Selection expansion & exploitation of mesenchymal cell plasticity on innovative biodegradable fibre scaffolds for tissue regeneration.

Reference	BBS/B/1728X
Principal Investigator / Supervisor	Professor Julian B Chaudhuri
Co-Investigators / Co-Supervisors	Professor Semali Perera
Institution	University of Bath
Department	Chemical Engineering
Funding type	Research
Value (£)	213,039
Status	Completed
Type	Research Grant
Start date	01/10/2004
End date	31/03/2008
Duration	42 months

Abstract

The future of tissue regeneration will depend, in large part, on procedures to isolate, expand and differentiate specific cell lineages. We propose to isolate adult human mesenchymal stem cells, expand these cells using innovative fibre scaffold/bioreactor technology, characterise the proteome of our stem cells and manipulate the selected lineages to form functional bone tissue. Reproducible selection protocols combined with phenotypic characterisation and robust cell expansion protocols would facilitate the treatment and the diagnosis of a range of inherited and degenerative musculoskeletal diseases which proteomic analysis will provide new markers for further identification and selection of mesenchymal lineages. Controlled expansion and differentiation of mesenchymal stem cells, as proposed, offer significant healthcare opportunities. (Joint with BBS/B/17271).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/17271 Selection expansion & exploitation of mesenchymal cell plasticity on innovative biodegradable fibre scaffolds for tissue regeneration.

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