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Selection expansion & exploitation of mesenchymal cell plasticity on innovative biodegradable fibre scaffolds for tissue regeneration.

ReferenceBBS/B/17271
Principal Investigator / Supervisor Professor Richard Oreffo
Co-Investigators /
Co-Supervisors		 Professor David O'Connor
Institution University of Southampton
DepartmentDevelopment Origin of Health and Disease
Funding typeResearch
Value (£) 307,135
StatusCompleted
TypeResearch Grant
Start date 01/09/2004
End date 31/05/2008
Duration45 months

Abstract

The future of tissue regeneration will depend, in large part, on procedures to isolate, expand and differentiate specific cell lineages. We propose to isolate adult human mesenchymal stem cells, expand these cells using innovative fibre scaffold/bioreactor technology, characterise the proteome of our stem cells and manipulate the selected lineages to form functional bone tissue. Reproducible selection protocols combined with phenotypic characterisation and robust cell expansion protocols would facilitate the treatment and the diagnosis of a range of inherited and degenerative musculoskeletal diseases which proteomic analysis will provide new markers for further identification and selection of mesenchymal lineages. Controlled expansion and differentiation of mesenchymal stem cells, as proposed, offer significant healthcare opportunities. (Joint with BBS/B/1728X).

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsAgeing, Industrial Biotechnology, Regenerative Biology, Stem Cells
Research PriorityX – Research Priority information not available
Research Initiative Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding SchemeX – not Funded via a specific Funding Scheme
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