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e-Fungi: an e-science infrastructure for comparative functional genomics in fungal species

ReferenceBBS/B/17166
Principal Investigator / Supervisor Professor Norman Paton
Co-Investigators /
Co-Supervisors		 Dr Mahmut Alpdemir, Dr Mike Cornell, Professor Simon Hubbard, Professor Stephen Oliver, Professor Magnus Rattray
Institution The University of Manchester
DepartmentComputer Science
Funding typeResearch
Value (£) 598,373
StatusCompleted
TypeResearch Grant
Start date 01/10/2004
End date 30/06/2008
Duration45 months

Abstract

In comparative functional genomics, relationships between genomes are studied in the light of rich functional data sets, on the transcriptome, proteome, metabolome and interactome. In the fungi, there is a wealth of sequence data from an ever-growing collection of species, many of significant medical or commercial importance, but much more patchy coverage in terms of functional data. As such, there is a pressing need to develop techniques and computational architectures that enable maximum benefits to be drawn from the rich data sets available. This project proposes to develop a service-based grid infrastructure for comparative functional genomics, and libraries of analyses for inter-relating these data sets. The resulting infrastructure will be designed, demonstrated and validated in the context of a study into how fungal pathogenicity - the ability to cause disease in a animal or plant host - first arose. (Joint with BBS/B/17174).

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsMicrobiology, Technology and Methods Development
Research PriorityX – Research Priority information not available
Research Initiative Bioinformatics and E Science Programme II (BEP2) [2003-2004]
Funding SchemeX – not Funded via a specific Funding Scheme
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