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The role of insulin signalling pathways in hippocampal learning and memory function.

Reference	BBS/B/16143
Principal Investigator / Supervisor	Professor Dominic Withers
Co-Investigators / Co-Supervisors	Professor Karl Giese, Professor Paola Pedarzani
Institution	University College London
Department	Department of Medicine
Funding type	Research
Value (£)	754,670
Status	Completed
Type	Research Grant
Start date	01/06/2004
End date	30/11/2007
Duration	42 months

Abstract

Correlative evidence implicates a role for insulin signalling in hippocampal function and for the cognitive impairment seen in type 2 diabetes. We will use existing murine models to study the physiological role of the major insulin signalling components IRS-1 and IRS-2 in hippocampal neurons. We will analyse behavioural, neuro-anatomical, intracellular signalling and electrophysiological end-points to directly investigate the role of these pathways in learning and memory. This programme of research, moving from the deletion of signalling molecules in specific neuronal populations through to behavioural end-points, will provide new insights into the mechanisms of learning and memory while providing an excellent environment for training in integrative research.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Integrative Analysis of Brain and Behaviour (IABB) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

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