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The hippocampal network in mice with impaired spatial learning

Reference	BBS/B/15996
Principal Investigator / Supervisor	Professor Ralf Schoepfer
Co-Investigators / Co-Supervisors	Professor John O'Keefe, Professor Mike Stewart
Institution	University College London
Department	Department of Pharmacology
Funding type	Research
Value (£)	637,874
Status	Completed
Type	Research Grant
Start date	01/10/2004
End date	30/09/2008
Duration	48 months

Abstract

Higher brain functions, including learning and memory, are based on the network properties of neurones, which in turn result from the interaction of cellular components and underlying molecular machinery. The latter can be altered by specific genetic manipulations and one of our laboratories has generated a mouse with an altered NMDAR-mediated coincidence system. These mice show substantially impaired spatial learning ability, and a deficit in synaptic plasticity. We will examine the hypothesis that the impaired learning ability in these mice is a consequence of structural modifications in the dendate gyrus, and ask whether their impaired cognitive function and synaptic properties correlate with network-level impairment, through the analysis of hippocampal place cells.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Neuroscience and Behaviour
Research Priority	X – Research Priority information not available
Research Initiative	Integrative Analysis of Brain and Behaviour (IABB) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

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