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Impact of systemic inflammation on cognition and the underlying mechanisms

Reference	BBS/B/15864
Principal Investigator / Supervisor	Emeritus Professor V Hugh Perry
Co-Investigators / Co-Supervisors	Dr Romola Bucks, Dr Yori Gidron, Professor Robert Grimble, Professor John Nicholas Pepys Rawlins
Institution	University of Southampton
Department	Centre for Biological Sciences
Funding type	Research
Value (£)	437,062
Status	Completed
Type	Research Grant
Start date	01/10/2004
End date	31/01/2008
Duration	40 months

Abstract

Systemic inflammation or infection gives rise to a fever and behavioural changes known as sickness behaviour. It has recently been shown that low levels of systemic inflammation not sufficient to cause a fever may impact on the brain, and transiently alter affective behaviour in mice and cognitive behaviour in man. We will investigate which aspects of cognition in mice are affected by subpyrogenic systemic inflammation and which cytokines are involved in signalling from the immune system to the brain. We will investigate whether vaccination, a low-grade systemic inflammatory challenge in man, impacts on cognition. We will investigate whether cytokine gene polymorphisms predict the impact of systemic inflammation on cognition. These studies will demonstrate how systemic inflammation may be of importance in our every day cognitive functioning and particularly in ageing.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Integrative Analysis of Brain and Behaviour (IABB) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

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