Award details

Interplay of transmitter systems in the prefrontal cortex underlying the attention-enhancing effects of nicotine.

Reference	BBS/B/15627
Principal Investigator / Supervisor	Dr Mohammed Shoaib
Co-Investigators / Co-Supervisors
Institution	Newcastle University
Department	Neurology Neurobiology and Psychiatry
Funding type	Research
Value (£)	255,485
Status	Completed
Type	Research Grant
Start date	14/10/2004
End date	13/02/2009
Duration	52 months

Abstract

The prefrontal cortex (PFC) is the central executive of the brain: attentional processes are central to its function, and are enhanced by nicotine acting at nicotinic acetylcholine receptors (nAChR). Characterisation of the modulation of dopamine-glutamate interactions by nAChR subtypes in rat PFC will be integrated with a behavioural paradigm of nicotine-enhanced attention. The cognitive effects of nicotinic drugs on the 5-choice serial reaction time task (CSRTT) will be characterised by Shoaib¿s group in Newcastle; in vitro and in vivo neurotransmitter release and immunocytochemical localisation of nAChR will be carried out by Wonnacott¿s group in Bath. These studies will be underpinned by the provision of resources and technical expertise by GSK, Harlow, and will elucidate the role of nAChR subtypes in attentional processes and their potential as targets for cognitive enhancers. (Joint with BBS/B/15600).

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	Neuroscience and Behaviour, Pharmaceuticals
Research Priority	X – Research Priority information not available
Research Initiative	Integrative Analysis of Brain and Behaviour (IABB) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/15600 Interplay of transmitter systems in the prefrontal cortex underlying the attention-enhancing effects of nicotine.

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search