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Factors affecting maintenance and differentiation of axial stem cell.
Reference
BBS/B/15481
Principal Investigator / Supervisor
Professor Valerie Anne Wilson
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Inst of Stem Cell Research
Funding type
Research
Value (£)
286,850
Status
Completed
Type
Research Grant
Start date
01/10/2004
End date
31/05/2008
Duration
44 months
Abstract
The mammalian anteroposterior axis depends for its elongation on a progenitor population contained in the primitive streak and tail bud. Fate mapping and potency analyses indicate that the progenitors are a novel stem cell type, which we term the axial stem cell. In this proposal, the normal proliferation and differentiation events in single cells will be studied in real time in cultured embryos. The molecules, which are important in controlling these events will be studied on generation of mouse lines which are able to induce varying levels of a wide range of molecules of interests in isolated, transgenically marked, cells in the context of a normal embryo. Finally, molecules which prove to bias cells towards maintenance as axial stem cells will be expressed stably and reversibly in transgenic mouse lines in order to provide a basis for isolating AS cell lines in culture.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
Stem Cells
Research Priority
X – Research Priority information not available
Research Initiative
Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme
X – not Funded via a specific Funding Scheme
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