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Mechanical conditioning incorporated within bioreactor systems influences the differentiation of human mesenchymal stem cells

Reference	BBS/B/15422
Principal Investigator / Supervisor	Professor David Alan Lee
Co-Investigators / Co-Supervisors	Professor Daniel Bader
Institution	Queen Mary University of London
Department	IRC - Biomedical Materials
Funding type	Research
Value (£)	214,428
Status	Completed
Type	Research Grant
Start date	01/11/2004
End date	31/10/2007
Duration	36 months

Abstract

Bone marrow contains mesenchymal stem cells (MSC), which exhibit prolonged proliferation in culture and are capable of differentiating into chondrocytes, osteoblasts, fibroblasts and adipocytes. These cells may be used in tissue engineered repair systems for cartilage and other skeletal tissues. It is well established that mechanical conditioning, applied using bioreactors, influences the metabolism of differentiated cells, however few studies have examined the effects of mechanical conditioning on cell differentiation. This study will test the hypothesis that defined mechanical conditioning regimes, associated with cyclic compressive loading, cyclic hydrostatic pressurisation or oscillatory fluid flow, may be used to selectively enhance chondrogenic or osteogenic differentiation and subsequent tissue formation by MSCs in 3-D constructs.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

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