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Glycosaminoglycan sulphation motif patterns as biomarkers of stem cell differentiation and proliferation
Reference
BBS/B/15414
Principal Investigator / Supervisor
Professor Bruce Caterson
Co-Investigators /
Co-Supervisors
Professor Clare Hughes
,
Dr Debbie Tudor
Institution
Cardiff University
Department
School of Biosciences
Funding type
Research
Value (£)
196,825
Status
Completed
Type
Research Grant
Start date
01/05/2004
End date
30/04/2007
Duration
36 months
Abstract
The objective of this study is to identify monoclonal antibody reagents that recognise specific sulphation motifs in glycosaminoglycans that are differentially expressed on proteoglycans during stem cell differentiation and proliferation. We hypothesise that these motifs facilitate the binding of different combinations of growth factors, cytokines and enzymes that regulate subsequent cell differentiation and/or proliferation. These reagents will be used to detect biomarker patterns of different stages of cell differentiation and thereby monitor the efficacy of different culture procedures used to maintain stem cells or drive them through differentiation pathways into tissue-specific cell lineages.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme
X – not Funded via a specific Funding Scheme
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