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Towards the isolation and characterisation of intestinal epithelial stem cells

Reference	BBS/B/15392
Principal Investigator / Supervisor	Professor Alan Clarke
Co-Investigators / Co-Supervisors	Dr Valerie Meniel
Institution	Cardiff University
Department	School of Biosciences
Funding type	Research
Value (£)	206,483
Status	Completed
Type	Research Grant
Start date	16/10/2004
End date	15/10/2007
Duration	36 months

Abstract

Although the crypt/villus axis of the small intestine is well characterised in terms of its cell biology, the precise identity of the stem cell population still eludes both in vitro and in vivo analyses. Recently, several potential new markers have been proposed, the majority of which mark both the putative stem cell population as well as early dysplastic intestinal lesions. This link between the stem cell population and early dysplasia has been acutely shown by the phenotype of mice mutant in the Wnt pathway, and also by the expression profiles of a number of Lef/Tcf target genes. This proposal seeks to exploit transgenic mice mutant within these pathways and their targets as reagents to facilitate the development of stem cell and stem cell related primary cultures, and subsequently to characterise these cultures through both microarray and subcutaneous injection.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

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