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The role of notch signalling in human embryonic stem (hES) cell self-renewal and differentiation

Reference	BBS/B/15074
Principal Investigator / Supervisor	Professor Peter Walter Andrews
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Biomedical Science
Funding type	Research
Value (£)	208,169
Status	Completed
Type	Research Grant
Start date	01/10/2004
End date	30/09/2007
Duration	36 months

Abstract

Notch signalling plays a crucial role in the maintenance and differentiation of many different stem cells. We have detected the presence of active Notch signalling in hES cells and their malignant counterparts EC cells both in the undifferentiated cells and during differentiation. This project proposes to investigate the role this Notch signalling plays in both the undifferentiated hES cells and during the process of differentiation. Investigation of the Notch system in hES cells will help to shed light on both the maintenance of the undifferentiated state and what controls the diversity of cell types observed when hES cells differentiate.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

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