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An international collaborative research effort to investigate the mechanisms controlling differentiation of human ES cells
Reference
BBS/B/15058
Principal Investigator / Supervisor
Professor Peter Walter Andrews
Co-Investigators /
Co-Supervisors
Dr Jonathan Draper
Institution
University of Sheffield
Department
Biomedical Science
Funding type
Research
Value (£)
376,487
Status
Completed
Type
Research Grant
Start date
01/04/2004
End date
30/09/2009
Duration
66 months
Abstract
Human ES cells, unlike murine ES cells, can spontaneously differentiate into trophoblast derivatives in vitro. By studying this differentiation pathway we plan to elucidate the mechanisms that maintain ES self-renewal and govern early differentiation decisions. In order to do this we plan to transfer new and pertinent mouse ES cell gene manipulation technologies developed in the laboratories of our Canadian collaborators (Drs Nagy and Rossant) to hES cells.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
Stem Cells
Research Priority
X – Research Priority information not available
Research Initiative
Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme
X – not Funded via a specific Funding Scheme
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