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The impact of telomerase reverse transcriptase expression on the characteristics of human and embryonic stem cells

Reference	BBS/B/14779
Principal Investigator / Supervisor	Professor Majlinda Lako
Co-Investigators / Co-Supervisors	Dr Lyle Armstrong, Dr Nicholas Hole, Professor Stefan Przyborski, Professor Tom Strachan
Institution	Newcastle University
Department	Clinical Medical Sciences
Funding type	Research
Value (£)	310,147
Status	Completed
Type	Research Grant
Start date	01/10/2004
End date	30/09/2007
Duration	36 months

Abstract

Human embryonic stem (ES) cells express the TERT telomerase reverse transcriptase gene and show telomerase activity, but both are downregulated during the differentiation process. Regulation of TERT and telomerase activity has not been investigated during embryonic development. Recently we have been able to derive a new human embryonic stem cell line (hES1-NCL) which we intend to use as a model system to mimic embryonic development. In the current proposal we wish to analyse TERT and telomerase regulation and their impact on human ES cell biology. This investigation will allow us not only to extend our basic knowledge of human ES cells but also design new systems which will have an impact on clinical and biotechnological aspects of this work such as large scale growth of human ES cells, elimination of undifferentiated cells from differentiated progeny intended for transplantation purposes and production of differentiated progeny that are less prone to replicative senescence.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

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