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Analysis of the molecular control of neural versus non-neural stem cell fate choices

Reference	BBS/B/14744
Principal Investigator / Supervisor	Dr Paul John Scotting
Co-Investigators / Co-Supervisors	Professor Roger Patient
Institution	University of Nottingham
Department	Sch of Biology
Funding type	Research
Value (£)	221,372
Status	Completed
Type	Research Grant
Start date	01/10/2004
End date	31/03/2008
Duration	42 months

Abstract

One of the first choices made by pluripotent embryonic stem cells is between neural and non-neural ectoderm. BMP and FGF signals play a central role in this choice. The SoxB1 family and GATA2/3 transcription factors are expressed in a manner that implicates them in this cell fate choice. Our data in zebrafish and data in other systems show that expression of the SoxB1 and GATA2/3 genes is affected by BMP and FGF signals. Moreover, SoxB1 and GATA factors have been shown to maintain a stem cell state (multipotency and self-renewal) and to control stem cell fate choice and differentiation. We will analyse the role of SoxB1/GATA2/3 in controlling stem cell fate, in particular their requirement for the response of cells to BMP and FGF signals.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

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