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The relevance of embryonic positional specification to neural stem cell differentiation

Reference	BBS/B/14736
Principal Investigator / Supervisor	Dr Brenda Williams
Co-Investigators / Co-Supervisors	Professor Jack Price
Institution	King's College London
Department	Neuroscience
Funding type	Research
Value (£)	353,651
Status	Completed
Type	Research Grant
Start date	27/10/2004
End date	26/03/2008
Duration	41 months

Abstract

Freshly isolated Neural Stem Cells (NSCs) show regional specification both in culture and after transplantation, that is, they generate only specific types of neurones and/or glia. Yet, expanded NSCs have a very broad developmental potential. If NSCs are to be an effective therapy we need to understand their biology, particularly (1) whether some regional specification is retained by expanded NSCs and whether this could affect their ability to generate the appropriate cell type after transplantation, and (2) how expansion extends the developmental capabilities of NSCs. We plan to test our hypothesis that the broad developmental potential displayed by expanded NSCs is associated with a change in expression of positional information genes and that for NSCs to respond correctly to environmental cues such genes must be correctly expressed.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

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