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Production of stem cells in the injured CNS by de-differentiation of the oligodendrocyte precursor population

Reference	BBS/B/14698
Principal Investigator / Supervisor	Professor James Fawcett
Co-Investigators / Co-Supervisors	Professor Robin Franklin, Dr Toru Kondo
Institution	University of Cambridge
Department	Cambridge Centre for Brain Repair
Funding type	Research
Value (£)	247,090
Status	Completed
Type	Research Grant
Start date	25/08/2004
End date	24/02/2008
Duration	42 months

Abstract

Repair of damage to the brain and spinal cord will require that there are stem or precursor cells present in regions of damage, and that they be manipulated to replace lost neurones and glia. CNS stem cells are only found in the subventricular region, and large numbers of them cannot migrate to injuries at any distance from this region. We propose to produce multipotential precursors in regions of CNS damage by using oligodendrocyte precursor cells, which proliferate massively in any region of pathology. These cells have been shown in vitro to be capable of dedifferentiation using BMPs and FGF. We will develop methods to dedifferentiate these cells in situ in the damaged CNS, and thereby provide large numbers of cells capable of replacing lost neurones and glia.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

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