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Plasticity of adult neuronal and pancreatic endocrine progenitor cells
Reference
BBS/B/14671
Principal Investigator / Supervisor
Professor Ann Logan
Co-Investigators /
Co-Supervisors
Professor Martin Berry
Institution
University of Birmingham
Department
Medical Sciences - Medicine
Funding type
Research
Value (£)
401,773
Status
Completed
Type
Research Grant
Start date
12/03/2004
End date
11/03/2008
Duration
48 months
Abstract
Regenerative medicine using stem cells or tissue progenitor populations to repopulate damaged/dysfunctional tissues has potential to cure diseases including diabetes and neurodegenerative disorders. We hypothesise that adult pancreatic endocrine and neural progenitor cells share sufficient plasticity that each can promote regeneration in the corresponding tissue. The aims are to phenotypically compare endocrine and neural progenitors, determine if they can be induced to switch lineage in vitro, and in vivo resulting in site specific tissue regeneration. Methods involve isolation, culture and molecular characterisation of pancreatic endocrine and neural progenitors plus in vitro and in vivo trans-differentiation studies.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme
X – not Funded via a specific Funding Scheme
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