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Transcriptional control of stem cell identity
Reference
BBS/B/1454X
Principal Investigator / Supervisor
Professor Berthold Gottgens
Co-Investigators /
Co-Supervisors
Professor Anthony Green
Institution
University of Cambridge
Department
Haematology
Funding type
Research
Value (£)
277,023
Status
Completed
Type
Research Grant
Start date
23/08/2004
End date
22/08/2007
Duration
36 months
Abstract
Transcriptional control is recognised as a key factor determining stem cell identity and subsequent differentiation. However, the transcriptional networks that control the formation and function of HSCs are still poorly understood, while virtually nothing is known about those acting in MSCs. We are proposing to study the transcriptional regulation of the endoglin and CD109 genes. This proposal aims to combine powerful genomic approaches (long range comparative sequence analysis) with transgenic mouse models. The two key objectives are: (1) Identification of cis-regulatory elements of the endoglin and CD109 genes that direct expression to HSCs and MSCs; (2) Molecular characterisation of MSC and HSC enhancers to identify transcriptional control mechanisms in these two adult stem cell types, and thus contribute to a molecular understanding of stemness.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme
X – not Funded via a specific Funding Scheme
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