Award details

Development of magnetic nanoparticle strategies manipulation and activation of stem cells in vitro and in vivo

Reference	BBS/B/14523
Principal Investigator / Supervisor	Professor Alicia El Haj
Co-Investigators / Co-Supervisors
Institution	Keele University
Department	Sch of Medicine
Funding type	Research
Value (£)	335,435
Status	Completed
Type	Research Grant
Start date	01/07/2004
End date	31/03/2008
Duration	45 months

Abstract

The use of stem cells in the form of cell-based therapies offer tremendous potential for disease treatment and reparative medicine. Central to this process will be the ability to target and activate these stem cells at required sites of injury and repair. We propose to investigate the processes by which magnetic nanoparticle technology can be applied to stem cell delivery systems in vivo and conditioning of stem cells both in vitro and vivo. In particular: i) to identify specific receptor and appropriate binding sites for magnetic nanoparticles on stem cells which will enable remote activation of signalling pathways via magnetic fields; ii) to model and characterise these processes in vitro using our prototype magnetic conditioning bioreactor systems; iii) to investigate stem cell mobilisation and activation using this technology in animal models in vivo. These enabling technologies offer tremendous healthcare benefits. (Joint with BBS/B/14515).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Stem Cell Science and Engineering Initiative (SCE) [2003-2005]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/14515 Development of magnetic nanoparticles strategies for manipulation and activation of stem cells in viitro and in vivo

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