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Structural proteomics; targeting biosynthetic pathways pathogenesis and DNA processing

ReferenceBBS/B/14450
Principal Investigator / Supervisor Professor Gregory Challis
Co-Investigators /
Co-Supervisors		 Professor Peter Derrick
Institution University of Warwick
DepartmentChemistry
Funding typeResearch
Value (£) 342,528
StatusCompleted
TypeResearch Grant
Start date 22/11/2004
End date 21/11/2009
Duration60 months

Abstract

St Andrews and Dundee Universities have established a Structural Proteomics Facility with their own and SHEFC funding. We now request funds for an inclusive and multidisciplinary scientific programme exploiting this facility. The science is driven by the applicants interests addressing significant problems in natural product biosynthesis, glycobiology, pathogenesis and DNA biology. Our key objective is that results will enhance knowledge in chemical biology and molecular microbiology. New technology will speed up gene to protein flow by fully automating cloning and solubility screening. We will develop new expression and protein purification systems designed to improve throughput of impactful research whilst maintaining high success rates. An integrated computing infrastructure will support bioinformatics, data management and crystallographic computing. (Joint with BBS/B/14426, BBS/B/14434, BBS/B/14442).

Summary

unavailable
Committee Closed Committee - Biomolecular Sciences (BMS)
Research TopicsMicrobiology, Structural Biology, Technology and Methods Development
Research PriorityX – Research Priority information not available
Research Initiative Structural Proteomics of Rational Targets (SPORT) [2003-2004]
Funding SchemeX – not Funded via a specific Funding Scheme
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