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The Membrane Protein Structure Initiative

Reference	BBS/B/14418
Principal Investigator / Supervisor	Professor Neil William Isaacs
Co-Investigators / Co-Supervisors	Professor Stephen Baldwin, Professor Per Bullough, Professor Richard Cogdell, Professor Jeremy Paul Derrick, Dr Declan Doyle, Professor John B C Findlay, Professor Robert Ford, Professor Peter Henderson, Dr Tomoko Iwata, Professor Paul Knox, Professor Michael McPherson, Dr Miroslav Papiz, Professor Simon Phillips, Dr Stephen Prince, Professor Mark Sansom, Professor Bonnie Wallace
Institution	University of Glasgow
Department	School of Chemistry
Funding type	Research
Value (£)	6,827,772
Status	Completed
Type	Research Grant
Start date	01/07/2004
End date	30/04/2010
Duration	70 months

Abstract

The Membrane Protein Structure Initiative (MPSI), a consortium of highly experienced membrane protein research groups from Glasgow, Leeds, Manchester, UMIST, Oxford, Sheffield, Imperial, Birkbeck, and CCLRC Daresbury will develop strategies for high throughput (HTP) expression, purification, characterisation, folding, crystallisation and structure determination of selected integral membrane proteins. The aims include development of robotics and recombinational cloning strategies for HTP production of expression constructs; the development of HTP screening methods for expression, solubilisation, purification and folding; the production of purified proteins for crystallisation and structure determination; and the HTP modelling of homologues.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	Structural Biology, Technology and Methods Development
Research Priority	X – Research Priority information not available
Research Initiative	Structural Proteomics of Rational Targets (SPORT) [2003-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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