Award details

The Bacillus Cell Factory: a new tool for the manufacturing industry

Reference	BBS/B/13799
Principal Investigator / Supervisor	Professor Colin Harwood
Co-Investigators / Co-Supervisors
Institution	Newcastle University
Department	School of Cell and Molecular Biosciences
Funding type	Research
Value (£)	209,785
Status	Completed
Type	Research Grant
Start date	01/12/2003
End date	30/11/2006
Duration	36 months

Abstract

Bacillus subtilis is widely used for the commercial production of industrial enzymes, particularly for the food and detergents industries. Its advantage is its capacity to secrete native Bacillus proteins into the culture medium at concentrations in excess of tens of grams per litre. However, experience with the use of this bacterium for the production of heterologous proteins has been mixed with, in most cases, generally low yields. The overall objective is to exploit knowledge of the Bacillus Sec-dependent preprotein secretion and associated quality control pathways to construct novel production strains with improved characteristics for the secretion of heterologous proteins for experimental studies, clinical trials and high throughput protein structural studies.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Applied Genomics (APG) [2000-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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