Award details

Function of the exon junction complex in the plant nucleolus

Reference	BBS/B/13519
Principal Investigator / Supervisor	Professor Peter Shaw
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	Cell and Develop Biology
Funding type	Research
Value (£)	242,388
Status	Completed
Type	Research Grant
Start date	16/10/2004
End date	15/10/2007
Duration	36 months

Abstract

Our recent proteomic analysis of the nucleolus in Arabidopsis has identified a number of interesting and unexpected nucleolar proteins. In particular, we have identified five proteins of the Exon Junction Complex (EJC). The EJC promotes mRNA export via the nuclear pore complex, and couples export to cytoplasmic nonsense-mediated decay and mRNA localisation. The discovery of the EJC proteins in the plant nucleolus is novel and suggests that this nuclear compartment influences overall expression of the plant proteome by modulating mRNA export, or in mRNA surveillance and nonsense-mediated decay processes. The objectives of the proposal are to use proteomic, molecular, and cell biological analyses to investigate the nature and function of EJC components in the nucleoli of plants. (Joint with BBS/B/13551)

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Proteomics and Cell Function (PCF) [2003-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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