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Regulation of the proteolytic cascade govering dorso-ventral cell fate determination in Drosophila early embryogenesis
Reference
BBS/B/12326
Principal Investigator / Supervisor
Professor Petros Ligoxygakis
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Biochemistry
Funding type
Research
Value (£)
230,004
Status
Completed
Type
Research Grant
Start date
01/05/2004
End date
30/04/2007
Duration
36 months
Abstract
Extracellular serine protease cascades have evolved in vertebrates and invertebrates to mediate rapid, local reactions to physiological or pathological cues. In order to gain insights on how these processes are regulated in vivo and in real time this application proposes to use the Drosophila dorso-ventral patterning cascade as an experimental system. We will investigate how a serine protease inhibitor controls the activation of the dorso-ventral system by interacting with one of its proteases. We will use a combination of genetic, biochemical and cell biological methods to demonstrate this interaction. The proposed study has the potential to reveal how proteolysis is regulated in real time in development and beyond.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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