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The interaction between an amino acid and a transcriptional activator
Reference
BBS/B/12202
Principal Investigator / Supervisor
Professor Richard Reece
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
198,234
Status
Completed
Type
Research Grant
Start date
01/04/2004
End date
31/03/2007
Duration
36 months
Abstract
The transcriptional factor responsible for the activation of the yeast proline utilisation genes, Put3p, has been purified and shown to activate transcription in vitro only in the presence of proline. In addition, a direct physical interaction between the activator and the amino acid has been shown. This protein will be analysed biochemically to determine the precise role of the metabolite in converting an inactive transcriptional regulator into its active form. This work will yield important information about both transcriptional control and metabolic pathway regulation. Understanding the mechanism of individual genetic switches will lead to a better comprehension of the processes involved in transcriptional activation and repression, and will give insights into how and why aberrant gene expression occurs.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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