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GTP sensing and regulation in Bacillus; structural studies of a GTP-dependent transcription factor and an essential GTPase
Reference
BBS/B/1213X
Principal Investigator / Supervisor
Professor Anthony Wilkinson
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Chemistry
Funding type
Research
Value (£)
220,844
Status
Completed
Type
Research Grant
Start date
01/03/2004
End date
28/02/2007
Duration
36 months
Abstract
Guanine nucleotide binding proteins function as molecular switches controlling numerous physiological processes in prokaryotes and eukaryotes. The purpose of the proposed work is to provide a structural basis for understanding GTP regulation of stationary phase gene expression in B. subtilis through crystallographic studies of the GTP-sensor CodY and its complexes with guanine nucleotides and DNA. We also aim to determine the structure of YloQ, an essential GTPase of unknown function, with a view to establishing its contribution to cellular physiology. We will also characterise the interactions between YloQ and the protein kinase PrkC, before crystallising the soluble cytoplasmic domain of PrkC and, if appropriate, initiating structural studies of its complex with YloQ.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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