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Structural and functional characterisation of the interaction between Staphylococcus aureus and the immune system

Reference	BBS/B/12121
Principal Investigator / Supervisor	Professor Jean van den Elsen
Co-Investigators / Co-Supervisors
Institution	University of Bath
Department	Biology and Biochemistry
Funding type	Research
Value (£)	207,246
Status	Completed
Type	Research Grant
Start date	25/10/2004
End date	24/10/2007
Duration	36 months

Abstract

Staphylococcus aureus expresses a range of surface adhesions which interact with host matrix and plasma proteins. We plan to characterise the structure and function of protein Sbi, a recently discovered cell wall-associated protein of S. aureus, and its interaction with host immune proteins, IgG and beta2-glycoprotein-I. Integrated structural (X-ray crystallography and NMR) and physico-chemical (e.g. calorimetry, surface plasmon resonance and analytical ultracentrifugation) data will provide exciting insights into bacterial-host interactions and could suggest new approaches for the development of therapeutics. The interaction between Sbi and beta2-glycoprotein-I is an ideal model for studying protein-protein interactions involving glycosylated multi-domain adhesion molecules.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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