Award details

Changes in the proteome of SUMO and NEDD8 during the cell cycle and in response to cellular stress

Reference	BBS/B/11974
Principal Investigator / Supervisor	Professor Ronald Hay
Co-Investigators / Co-Supervisors	Dr Catherine Botting
Institution	University of St Andrews
Department	Biology
Funding type	Research
Value (£)	265,901
Status	Completed
Type	Research Grant
Start date	01/06/2004
End date	30/09/2005
Duration	16 months

Abstract

Post-translational modification of protein substrates by the ubiquitin-like proteins SUMO and NEDD8 is required for important cellular processes in eukaryotes, ranging from cell cycle progression to stress responses. SUMO and NEDD8 attachment alters the function of modified proteins, changing their enzymatic activity, sub-cellular localisation or incorporation into multi-protein complexes. To date however only a limited number of targets for modification have been identified and straightforward proteomic approaches have been confounded by the requirement to preserve the modified state by cell lysis under highly denaturing conditions. Recently however we have circumvented these problems and our objective in this proposal is to characterise the SUMO and NEDD8 sub-proteomes and determine how their composition changes as cells progress the cell cycle and respond to stress.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Proteomics and Cell Function (PCF) [2003-2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/B/11974/2 Changes in the proteome of SUMO and NEDD8 during the cell cycle and in response to cellular stress

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