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Regulation of proliferation control by discs-large associated proteins in Drosophila
Reference
BBS/B/11869
Principal Investigator / Supervisor
Dr Daimark Bennett
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Zoology
Funding type
Research
Value (£)
202,969
Status
Completed
Type
Research Grant
Start date
01/10/2004
End date
30/09/2007
Duration
36 months
Abstract
Membrane-Associated Guanylate Kinase proteins (MAGUKs) are involved in clustering cell adhesion molecules, receptors and intracellular signalling molecules into function membrane-associated protein complexes. Discs-large (D1g), the prototypic member of this family of proteins, is required for cell polarity, proliferation control and cell junction structure in Drosophila epithelia. Whilst much is known about the development roles of D1g, many details of the composition, activity and regulation of D1g complexes remains to be elucidated. This project aims to further our understanding of the regulation of proliferation control by D1g and D1g-associated proteins in Drosophila by a combination of genetic and proteomics approaches.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Proteomics and Cell Function (PCF) [2003-2004]
Funding Scheme
X – not Funded via a specific Funding Scheme
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