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Cytoplasmic myosin phosphatases in Drosophila
Reference
BBS/B/1180X
Principal Investigator / Supervisor
Dr Luke Alphey
Co-Investigators /
Co-Supervisors
Dr Daimark Bennett
Institution
University of Oxford
Department
Zoology
Funding type
Research
Value (£)
231,531
Status
Completed
Type
Research Grant
Start date
01/07/2004
End date
31/12/2007
Duration
42 months
Abstract
The actomyosin cytoskeleton is crucial for regulating cell shape, developmental movement and cell adhesion. Myosin II, the major non-muscle myosin, is regulated by phosphorylation of myosin regulatory light chain (MRLC). We propose to investigate the regulation of cytoplasmic (non-muscle) myosin in Drosophila, using genetic as well as biochemical methods. Our preliminary data suggest that there may be two sub-cellular pools of non-muscle myosin, regulated by different myosin phosphatase complexes. Furthermore, homology between the relevant Drosophila and vertebrate proteins suggests that this may also apply to vertebrates, and that the role of vertebrate MYPT proteins needs to be re-evaluated.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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