Award details

Mode of action and function of antisense RNA in a model eukaryote

Reference	BBS/B/11710
Principal Investigator / Supervisor	Dr Susan Crosthwaite
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	251,055
Status	Completed
Type	Research Grant
Start date	01/07/2004
End date	31/12/2007
Duration	42 months

Abstract

Recently, we have discovered an endogenous antisense RNA that is part of the circadian clockwork of Neurospora crassa. This antisense RNA is convergently transcribed from the frequency (frq) locus, whose sense products are well-studied components of Neurosporas clock. The unexpected discovery of antisense frq RNA marks the first time that an apparently non-coding RNA is implicated in the process of biological timekeeping and thus, we know little about its action within the circadian system. It is the aim of this proposal to elucidate mode of action and function of antisense frq, by studying its expression under environmental conditions relevant for the maintenance of rhythmicity and by identifying its cellular interactions and targets. We hope to discover as yet unknown modes of gene regulation not only significant for biological clocks but also for other important cellular processes.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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