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Investigation of the role of type IV collagens in the regulation of Dpp signalling in Drosophila
Reference
BBS/B/11672
Principal Investigator / Supervisor
Professor Hilary Ashe
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
215,756
Status
Completed
Type
Research Grant
Start date
28/09/2004
End date
27/09/2007
Duration
36 months
Abstract
In Drosophila, the TGF-beta ligands Decapentaplegic (Dpp) and Screw (Scw) pattern the dorsal ectoderm of the embryo. I have found that mutations in the gene encoding a Drosophila type IV collagen disrupt Dpp/Scw signalling in the embryo. Type IV collagens are major components of basement membranes which are specialised forms of extracellular matrix. This proposal aims to analyse how type IV collagens augment Dpp/Scw signalling in Drosophila using genetic and biochemical approaches. Differences in Dpp/Scw levels, distribution and their ability to diffuse in mutant embryos will be investigated. Results from these studies will improve understanding of how secreted signalling molecules navigate extracellular spaces.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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