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Mechanism of a bacteriophage defence system in streptomyces coelicolor
Reference
BBS/B/11400
Principal Investigator / Supervisor
Professor Margaret Smith
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
School of Medical Sciences
Funding type
Research
Value (£)
234,817
Status
Completed
Type
Research Grant
Start date
01/08/2004
End date
31/07/2007
Duration
36 months
Abstract
Bacteria and their bacteriophage are locked in an evolutionary arms race which has resulted in a rich diversity of offensive/defensive strategies shaping bacterial and phage genomes. This project concerns a sophisticated phage defence strategy, phage growth limitation or Pg1, that was originally described in Streptomyces coelicolor A3(2) but may be more generally present in the prokaryotic world. The aims of this project are to study the mechanism of Pg1 in S. coelicolor by investigating the activities of the four proteins, Pg1W, Pg1X, Pg1Y and Pg1Z using genetic, biochemical and proteomic approaches and to investigate the role of Pg1-like systems in other bacteria.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Integrated Epigenetics (EPI) [2003]
Funding Scheme
X – not Funded via a specific Funding Scheme
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