Award details

Investigating the mechanism of internal ribosome entry using a novel genetic screen

Reference	BBS/B/11257
Principal Investigator / Supervisor	Dr Cornelia Huiberdina de Moor
Co-Investigators / Co-Supervisors	Professor Anne Willis
Institution	University of Nottingham
Department	Sch of Biomedical Sciences
Funding type	Research
Value (£)	53,768
Status	Completed
Type	Research Grant
Start date	13/04/2004
End date	12/04/2005
Duration	12 months

Abstract

Internal ribosome entry is an mRNA specific of translation initiation frequently found on mRNAs encoding proteins determining cell proliferation and survival. The internal ribosome entry sites (IRESes) of the c-myc and Apaf-1 mRNAs are in the 5-prime UTRs of their mRNAs. They have been extensively characterised, both functionally and structurally. Different RNA binding proteins have been identified as IRES trans-acting factors (ITAFs) and this partially explains the cell type specificity of these IRESes. In the study we propose to develop a novel genetic screen for use in tissue culture cells and use it to identify new IRES regulators. This screen could become a useful tool in the study of the regulation of protein levels in general.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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