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Understanding the essential role of ACN-1 in nematode moulting

Reference	BBS/B/11192
Principal Investigator / Supervisor	Professor Elwyn Isaac
Co-Investigators / Co-Supervisors	Mr D Brook
Institution	University of Leeds
Department	Inst of Integrative & Comparative Biolog
Funding type	Research
Value (£)	231,391
Status	Completed
Type	Research Grant
Start date	17/05/2004
End date	16/05/2007
Duration	36 months

Abstract

ACN-1 is a unique non-peptidase member of the M2 peptidase family found only in nematodes. It is present in hypodermal seam cells, developing vulva and male spicules. It is essential for hypodermal cell fusion, moulting, male tail development and possibly vulva organogenesis in C. elegans, however, the molecular/cellular basis of ACN-1 action is not known. We propose to define the cellular role of ACN-1 in moulting and sex organ morphogenesis in C. elegans. Moulting and reproduction are critical events in the life-cycle of nematodes, many of which are important pest species. A better understanding of these events will provide new avenues to the design and discovery of new control strategies.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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