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Functional expression of Drosophila candidate taste receptor genes Gr
Reference
BBS/B/11176
Principal Investigator / Supervisor
Dr Sylwester Chyb
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Life Sciences - Biology
Funding type
Research
Value (£)
270,291
Status
Completed
Type
Research Grant
Start date
01/06/2004
End date
31/07/2007
Duration
38 months
Abstract
Recent studies have revealed a large superfamily of Drosophila gustatory receptor (Gr) genes. Gr genes encode seven-transmembrane (7TM) G protein-coupled receptors (GPCR) expressed in subsets of taste sensilla and likely to be involved in the reception of varied taste stimuli. Based on the structural homology Gr gene products have been grouped into 7 subfamilies. Gr5a which we have recently characterised as a taste receptor narrowly tuned to trehalose, along with the Gr64 cluster and Gr61d, form subfamily II. We request funding for heterologous expression and functional characterisation of Drosophila Gr candidate taste receptor genes, Gr64a-f and Gr61d.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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