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Light-regulated gene expression in Myxococcus xanthus: the mechanism of action of anti-repressor CarS on repressor CarA

Reference	BBS/B/11141
Principal Investigator / Supervisor	Professor David Hodgson
Co-Investigators / Co-Supervisors	Professor Robert Conlan, Dr Helena Wright
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	250,525
Status	Completed
Type	Research Grant
Start date	01/08/2004
End date	31/03/2009
Duration	56 months

Abstract

Light-regulated gene expression in the bacterium M. xanthus involves the action of a novel anti-repressor CarS, which antagonises the repressor CarA. CarA is a member of the MerR transcriptional regulator family but acts solely as a repressor of the carotenoid biosynthesis operon, crtEBDC. Expression of CarS is light-regulated and the protein has the novel ability to disassociate CarA from its operator. The objective of the proposal is to characterise the mechanism of action of CarS. The objective will be achieved by genetic dissection of CarA and CarS and biophysical characterisation. The latter includes solving the crystal structure of CarS and CarA and surface plasmon resonance analysis of CarA, CarS and the CarA operator.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	Microbiology, Structural Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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