Award details

Investigation and optimisation of steroid-based electroactive anionophores

Reference	BBS/B/11044
Principal Investigator / Supervisor	Professor Anthony Davis
Co-Investigators / Co-Supervisors	Professor David Sheppard
Institution	University of Bristol
Department	Chemistry
Funding type	Research
Value (£)	200,610
Status	Completed
Type	Research Grant
Start date	13/09/2004
End date	12/01/2008
Duration	40 months

Abstract

In collaboration with a group in the USA, the proposers have recently demonstrated a novel class of agents for ion transport across biological membranes. Instead of transporting cations, like the ionophores commonly used in physiology, these cholapods are selective for anions. Moreover they are electroactive, being capable of transporting anions without co-transport of cations, and thus of moderating membrane conductivity and transmembrane potential differences. The aim of the proposed work is to investigate and optimise these molecules to the point where they can be used as tools for membrane research, modifying electrical properties without affecting cation concentrations, and serving as models for natural anion transport.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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