Award details

Developmental dynamics cell-cell and cell-matrix interactions in the avian corneal stroma

Reference	BBS/B/10994
Principal Investigator / Supervisor	Professor Andrew Quantock
Co-Investigators / Co-Supervisors	Professor Bruce Caterson, Dr James Ralphs
Institution	Cardiff University
Department	Optometry and Vision Sciences
Funding type	Research
Value (£)	310,622
Status	Completed
Type	Research Grant
Start date	01/05/2004
End date	31/05/2008
Duration	49 months

Abstract

The chicken cornea attains adult levels of transparency in a one week window before hatching at the time of considerable structural and compositional change. But what are the chief structural alterations and what compositional changes drive these? We will carefully chart structural matrix change, especially those of the key collagen-proteoglycan relationships, and correlate them with corneal transparency. Spatial and temporal changes in the network or cytoskeletal proteins/junctional complexes will be investigated and a link with the extracellular environment explored. The work will provide much-needed information about corneal structure-function relationships, developmental dynamics and cell-cell/cell-matrix interactions.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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