Award details

Post-genomic analysis of hypothalamic control of body weight: role of histaminergic signalling

Reference	BBS/B/10765
Principal Investigator / Supervisor	Professor Fran Ebling
Co-Investigators / Co-Supervisors
Institution	University of Nottingham
Department	Sch of Biomedical Sciences
Funding type	Research
Value (£)	231,749
Status	Completed
Type	Research Grant
Start date	01/10/2004
End date	30/09/2007
Duration	36 months

Abstract

The aim of this project is to understand the role of hypothalamic hisaminergic systems in the long-term control of energy metabolism. Our studies have identified a profound reduction in expression of the H3 receptor in the dorsal tuberomammillary nucleus (DTM) in a seasonal mammal at the phase of the annual cycle when they catabolise fat reserves. We will test the hypothesis that increased histaminergic tone from the DTM is involved in long-term body weight regulation. This will be accomplished by combining i) genomic studies to identify further changes in gene expression in the DTM associated with decreased H3 signalling, and ii) in vivo tests of the effect of pharmacological manipulation of H3 signalling on appetite and energy balance. (Joint with BBS/B/13993)

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search