Award details

Elucidation of functional roles of bone morphogenetic proteins (BMPSs) in bovine ovarian follicles

Reference	BBS/B/10439
Principal Investigator / Supervisor	Professor Philip Knight
Co-Investigators / Co-Supervisors	Dr Claire Glister
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	283,023
Status	Completed
Type	Research Grant
Start date	01/10/2004
End date	30/09/2007
Duration	36 months

Abstract

The aim is to advance the understanding of the recently discovered ovarian BMP system. Building on our substantial preliminary work, this will be achieved using ovarian immunohistochemistry (to deteriner the spatio-temporal pattern of expression of BMPs and BMP receptors during bovine folliculogenesis) together with functional experiments involving well-defined in vitro models (bovine theca and granulosa cells in primary culture). Functional studies will use different approaches (including RNAi, immunoneutralisation, icc, ELISA) to test several hypotheses concerning autocrine/paracrine actions of BMPs. Given the lack of data on ovarian BMP secretion, importantly, we will develop novel immunoassays for bovine BMP-4, -6 and-7 and use these to study factors regulating BMP secretion by theca and granulosa cells.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search